Benazepril / hydrochlorothiazide Side Effects

Medically reviewed by Drugs.com. Last updated on Dec 8, 2023.

Applies to benazepril / hydrochlorothiazide: oral tablet.

Serious side effects

Along with its needed effects, benazepril / hydrochlorothiazide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking benazepril / hydrochlorothiazide:

Less common

• Blurred vision
• confusion
• decreased urination
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• dry mouth
• fast, slow, or irregular heartbeat
• muscle cramps or pain
• numbness, tingling, pain, or weakness in the hands or feet
• rapid breathing
• seizures
• sunken eyes
• sweating
• thirst
• trembling
• unusual tiredness or weakness
• weakness and heaviness of the legs
• wrinkled skin

Rare

• Black, tarry stools
• bloating
• burning, crawling, itching, numbness, prickling, "pins and needles" , or tingling feelings
• chest pain
• chills
• constipation
• cough or hoarseness
• darkened urine
• diarrhea
• dizziness or lightheadedness
• feeling of constant movement of self or surroundings
• fever
• headache
• indigestion
• loss of appetite
• lower back or side pain
• nausea
• painful or difficult urination
• pains in the stomach or side, possibly radiating to the back
• persistent non-healing sore
• pink growth
• reddish patch or irritated area
• sensation of spinning
• shiny bump
• sore throat
• sores, ulcers, or white spots on the lips or in the mouth
• swollen glands
• trouble breathing
• unusual bleeding or bruising
• vomiting
• white, yellow or waxy scar-like area
• yellow eyes or skin

Other side effects

Some side effects of benazepril / hydrochlorothiazide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Cough
• decreased interest in sexual intercourse
• excessive muscle tone
• feeling of constant movement of self or surroundings
• inability to have or keep an erection
• loss in sexual ability, desire, drive, or performance
• muscle stiffness
• muscle tension or tightness
• sensation of spinning
• sleepiness or unusual drowsiness

Rare

• Blistering, peeling, loosening of the skin
• diarrhea
• hives or welts, itching, skin rash
• increased sensitivity of skin to sunlight
• joint or muscle pain
• pinpoint red or purple spots on the skin
• redness of the skin
• redness or other discoloration of the skin
• red irritated eyes
• red skin lesions, often with a purple center
• severe sunburn

For Healthcare Professionals

Applies to benazepril / hydrochlorothiazide: oral tablet.

General

The most common side effects were dizziness, fatigue, headache, and cough.^[Ref]

Nervous system

Common (1% to 10%): Dizziness, postural dizziness, headache, hypertonia, somnolence

Uncommon (0.1% to 1%): Paresthesia, taste perversion, tinnitus, syncope, hypesthesia

Hydrochlorothiazide:

Postmarketing reports: Lightheadedness, headache, paresthesia^[Ref]

Respiratory

Common (1% to 10%): Cough, upper respiratory infection, rhinitis, sinusitis

Uncommon (0.1% to 1%): Epistaxis, bronchitis, voice alteration

Benazepril:

Postmarketing reports: Eosinophilic pneumonitis

Hydrochlorothiazide:

Postmarketing reports: Respiratory distress, pneumonitis, pulmonary edema^[Ref]

Other

Common (1% to 10%): Fatigue, vertigo, flu syndrome

Uncommon (0.1% to 1%): Asthenia, chest pain, fever, chills

Hydrochlorothiazide:

Postmarketing reports: Vertigo, weakness, pyrexia, asthenia^[Ref]

Genitourinary

Common (1% to 10%): Impotence, urinary frequency

Uncommon (0.1% to 1%): Urinary tract infection^[Ref]

Gastrointestinal

Common (1% to 10%): Nausea

Uncommon (0.1% to 1%): Vomiting, diarrhea, dyspepsia, constipation, dry mouth, abdominal pain, gastroenteritis, flatulence, tooth disorder

Hydrochlorothiazide:

Postmarketing reports: Pancreatitis, small bowel angioedema, sialadenitis, vomiting, diarrhea, cramping, nausea, gastric irritation, constipation^[Ref]

Musculoskeletal

Common (1% to 10%): Back pain

Uncommon (0.1% to 1%): Arthralgia, myalgia, neck pain, arthritis

Hydrochlorothiazide:

Postmarketing reports: Muscle spasm^[Ref]

Dermatologic

Uncommon (0.1% to 1%): Rash, sweating, photosensitivity, pruritus, alopecia

Benazepril:

Postmarketing reports: Stevens-Johnson syndrome, pemphigus

Hydrochlorothiazide:

Postmarketing reports: Purpura, urticaria, rash, photosensitivity, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis^[Ref]

Psychiatric

Uncommon (0.1% to 1%): Insomnia, nervousness, libido decreased, abnormal dreams

Hydrochlorothiazide:

Postmarketing reports: Restlessness^[Ref]

Cardiovascular

Uncommon (0.1% to 1%): Palpitations, flushing, peripheral vascular disorder, tachycardia

Hydrochlorothiazide:

Postmarketing reports: Necrotizing angiitis^[Ref]

Ocular

Uncommon (0.1% to 1%): Abnormal vision, retinal disorder, conjunctivitis

Hydrochlorothiazide:

Postmarketing reports: Transient blurred vision, xanthopsia^[Ref]

Metabolic

Uncommon (0.1% to 1%): Anorexia

Hydrochlorothiazide:

Postmarketing reports: Anorexia, hyperglycemia, glycosuria, hyperuricemia^[Ref]

Immunologic

Uncommon (0.1% to 1%): Infection

Hydrochlorothiazide:

Postmarketing reports: Anaphylactoid reactions^[Ref]

Renal

Frequency not reported: Serum creatinine increased, BUN increased^[Ref]

Hematologic

Benazepril:

Postmarketing reports: Hemolytic anemia, thrombocytopenia

Hydrochlorothiazide:

Postmarketing reports: Aplastic anemia, agranulocytosis, leukopenia, neutropenia, thrombocytopenia^[Ref]

Hepatic

Benazepril:

Postmarketing reports: Pancreatitis

Hydrochlorothiazide:

Postmarketing reports: Intrahepatic cholestatic jaundice^[Ref]

Endocrine

Hydrochlorothiazide:

Postmarketing reports: Parathyroid gland changes with hypercalcemia and hypophosphatemia^[Ref]

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer